Comparison of Biochemical Recurrence Free Survival between Pelvic Lymph Node Metastasis and Periprostatic Lymph Node Metastasis of Prostate Cancer: A Case-Control Study
Nilda Gonzalez-Roibon, Jeong S Han, Stephen Lee, Rajni Sharma, Zhaoyong Feng, Sehbal Arslankoz, Nathaniel Smith, Philip M Pierorazio, Elizabeth Humphreys, Theodore L Deweese, Alan W Partin, Trinity J Bivalacqua, Misop Han, Bruce Trock Trock, George J Netto. Johns Hopkins Hospital, Baltimore, MD; Hacettepe University School of Medicine, Ankara, Turkey
Background: The purpose of our study is to assess the pathologic characteristics and the prognostic significance of periprostatic lymph node metastasis of prostate cancer (PCa). The latter was performed by comparing biochemical recurrence (BCR) free survival in cases of periprostatic lymph node metastasis with that of matched controls showing pelvic lymph node metastasis.
Design: We identified 17 patients who underwent radical prostatectomy in our hospital with positive periprostatic lymph nodes and negative pelvic lymph nodes between 1984 and 2011. Of these, 15 patients had available follow-up information. Cases were matched 1:2 to controls for pertinent clinicopathologic parameters.
Results: Positive periprostatic lymph nodes were predominantly found in the posterior base and mid postero-lateral locations. Overall higher rate of positive margins, smaller lymph node and metastasis size were encountered in cases compared to controls. At 5 years post prostatectomy, 69% of cases were free of BCR, while 26% of controls remained BCR-free. This result suggested that patients with periprostatic node metastasis appeared to have a lower risk of BCR. However, the difference did not reach statistical significance (p=0.072). The same was true when adjusted for the effect of PSA, surgical margin status, size of lymph nodes, size of metastasis, age and year of surgery.
Conclusions: Patients with periprostatic node metastasis may have a lower risk of BCR compared to those with metastasis to pelvic lymph nodes. Future analysis of larger cohorts will help establish the biologic significance of PCa metastasis to periprostatic lymph nodes.
Category: Genitourinary (including renal tumors)
Monday, March 4, 2013 1:00 PM
Poster Session II # 149, Monday Afternoon