Prognosis of Retroperitoneal Sarcomas Owing to Their Histologic Subtypes: A Large Multicentre Retrospective Analysis Fom the French Sarcoma Group
Maud Toulmonde, Agnes Neuville, Philippe Terrier, Dominique Ranchere-Vince, Veronique Brouste, Antoine Italiano, Jean-Michel Coindre. Institut Bergonié, Bordeaux, France; Institut Gustave Roussy, Villejuif, France; Centre Léon Bérard, Lyon, France
Background: Retroperitoneal sarcomas (RPS) are mainly made up of liposarcomas (LPS) and leiomyosarcomas (LMS) that have distinct behaviors. Unclassified pleomorphic sarcomas (UPS) are a heterogeneous group whose proportion in RPS has decreased in time with the recognition that a large part was in fact dedifferentiated LPS. Because of their rarity, these subtypes have been mainly studied and managed as a whole. The aim of this multicentre study was to describe and analyze the behavior and prognosis of the different histological subtypes existing in RPS.
Design: We conducted a retrospective analysis of patients > 18 year-old diagnosed with a RPS in French cancer centers between 01/01/1988 to 31/12/2008.
Results: 313 women and 273 men were included, 57 years-old mean age (range 18-89). The main diagnoses were 244 dedifferentiated liposarcoma (DDLPS, 41.5%), 135 well differentiated liposarcoma (WDLPS, 23%), 109 LMS (18.5%) and 42 UPS (7%). Evolution patterns owing to histology are given in [Table 1]. On multivariate analyses, significant prognostic factors for LR relapse were tumor opening (p=0.01) for WDLPS, expert surgeon (p=0.01) and radiotherapy (p=0.03) for DDLPS. Significant prognostic factors for overall survival were multifocality (p=0.02) and LR involvement (p=0.01) pour WDLPS, grade (p=0.015) for DDLPS, LR involvement (p=0.035) and type of surgery (p=0.018) for LMS.
|Nb M0 operated||124||219||83||34|
|Nb R0/R1 (%)||103 (80.5)||156 (71)||75 (90.4)||21 (61.8)|
|Nb LR relapse (%)||56 (54)||93 (60)||31 (41)||15 (71)|