When Worlds Collide: A Series of Genitourinary Collision Tumors
Waseem Anani, Somak Roy, Milon Amin, Uma Rao, Liron Pantanowitz, Anil Parwani. University of Pittsburgh Medical Center, Pittsburgh, PA
Background: Primary genitourinary neoplasms as well as metastasis from other sites to the genitourinary tract are common. In contrast, collision tumors, characterized by coexistence of phenotypically and genotypically distinct tumors at the same site, are distinctly rare in the genitourinary tract and pose a diagnostic challenge. The goal of this study is to present a series of such cases from a single institution highlighting the unusual clinicopathologic features of these tumors.
Design: Nine cases were retrospectively identified from our surgical pathology files and included internal and consultation cases (2006-2012). All tumors were identified by H&E and immunohistochemistry as distinct primary neoplasms. In select cases, the final diagnosis was substantiated by fluorescence in-situ hybridization.
Results: The study included 9 patients, 8 males and 1 female ranging in age from 34-84 years (mean 66.3 years). Collision tumors composed 7 of the 8 cases with the site of the collision as follows: kidney (6), bladder (2), and pelvis (1). All but one of the collision tumors involved two malignant neoplasms.
|Case||Primary Tumor||Secondary Tumor||Location||Age||Sex|
|1||Chromophobe Renal Cell Carcinoma||Neuroendocrine/Carcinoid Tumor||Kidney||34||M|
|2||Clear Cell Renal Cell Carcinoma||Pulmonary Adenocarcinoma||Kidney||57||M|
|3||Clear Cell Renal Cell Carcinoma||Poorly Differentiated Carcinoma of Urothelial Origin||Kidney||64||M|
|5||Clear Cell Renal Cell Carcinoma||Chromophobe Renal Cell Carcinoma||Kidney||76||M|
|6||Chromophobe Renal Cell Carcinoma||Papillary Renal Cell Carcinoma||Kidney||81||M|
|7||Pleomorphic Liposarcoma||Prostatic Adenocarcinoma||Pelvis||70||M|
|8||Urothelial Carcinoma||Prostatic Adenocarcinoma||Bladder||73||M|
|9||Urothelial Carcinoma||Prostatic Adenocarcinoma||Bladder||84||M|