Comparison of Immunohistochemical Profiles of Papillary Renal Cell Carcinoma Subtypes
Ahmed Alomari, Harriet Kluger, Kenneth Haines, Dinesh Singh, Manju L Prasad, Adebowale J Adeniran. Yale School of Medicine, New Haven, CT
Background: Papillary renal cell carcinoma (PRCC) is characterized morphologically by the presence of fibrovascular cores, lined by papillae of malignant epithelial cells. It is further sub-classified into 2 types based on cell type. Type 2 tumors are generally believed to have a poorer prognosis than type 1 tumors. This prognostic difference has led some to believe that some of the type 2 tumors may actually represent a separate entity from PRCC. This study was designed to compare the immunohistochemical profiles in both subtypes of PRCC.
Design: A tissue microarray block with 124 cases of PRCC was constructed. The tumors were stained with the following diagnostic antibodies: CK7, EMA, CD10, CAIX, vimentin, CK903, C-kit, racemase, PAX-8, PAX-2 and CEA. A stain was deemed to be positive if it demonstrated at least weak intensity in at least 10% of the tumor cells. Intensity was scored as 1+, 2+ and 3+ for weak, moderate and strong intensity, respectively. A score of 0 was given for negative staining.
Results: Results of the immunohistochemical stains are listed in Table 1.
|Type 1||Type 2||Mixed|