Gastrointestinal Stromal Tumors (GISTs): Molecular Analysis of KIT/PDGFRA/BRAF Genes Refines Risk Assessment (Register Study)
Sabrina Rossi, Rosalba Miceli, Luisa Toffolatti, Daniela Gasparotto, Giovanna Gallina, Alessandra Marzotto, Enrico Scaramel, Luca Messerini, Italo Bearzi, Guido Mazzoleni, Carlo Capella, Gianluigi Arrigoni, Aurelio Sonzogni, Angelo Sidoni, Luigi Mariani, Chiara Gnocchi, Roberta Valenti, Roberta Maestro, Alessandro Gronchi, Paolo G Casali, Angelo P Dei Tos. General Hospital, Treviso, Italy; Istituto Nazionale Tumori, Milano, Italy; CRO, Aviano, Italy; Firenze University School of Medicine, Firenze, Italy; University of Marche, Ancona, Italy; General Hospital, Bolzano, Italy; Macchi Fondation, Varese, Italy; San Raffaele Hospital, Milano, Italy; General Hospital, Bergamo, Italy; Medical School, Perugia, Italy; Novartis Farma, Origgio, Italy
Background: We analyzed a subset of naive GISTs from the REGISTER series, to assess whether KIT/PDGFRA/BRAF mutations are relevant to prognosis.
Design: DNA was analyzed in 451/526 GISTs previously evaluated to generate a OS nomogram, based on age, tumor site, as well as mitotic index (MI) and size both considered as continuous variables. Univariable and multivariable analyses were performed. A backward selection procedure was applied to the multivariable model to automatically generate prognostically homogeneous groups.