Histologic Follow-Up for Atypical Endocervical Cells
Bryan L Janssen, Michael J Thrall. Methodist Hospital, Houston, TX
Background: In previous literature on atypical glandular cells, using conventional and non-imaged liquid-based Papanicoalou (Pap) tests, squamous dysplasia was about twice as likely to be found on follow-up as glandular neoplasia (Davey et al. APLM 2000). We have examined the performance of atypical endocervical cell categories in our experience with imager-aided liquid-based screening.
Design: Cases from the categories of atypical endocervical cells (AECC), atypical endocervical cells favor neoplastic (FN), and atypical endocervical cells favor adenocarcinoma in situ (AIS) were collected. These were correlated with subsequent histologic follow-up. Cases were stratified into two patient groups: a dysplasia clinic and the general population. The two-tailed Fischer exact test was used to calculate p-values.
Results: Over a six year period, 120 cases were identified with tissue follow-up available in 76 (63.3%).
|Available tissue follow-up||49 (56.9%)||10 (66.7%)||17 (89.5%)||76 (63.3%)|
|Average age (range)||40 (19-66)||36 (28-58)||34 (21-67)||37.5 (19-67)|
|HGSIL (CIN 2/3)||8†||5‡||6†||19 (25.0%)|
|LGSIL (HPV/CIN I)||7∗,∗∗||0||2||9 (11.8%)|
|Cervical adenocarcinoma||1||1||0||2 (2.6%)|
|Endometrial adenocarcinoma||1∗∗||0||1||2 (2.6%)|
|∗1 with AIS and LGSIL|
|∗∗1 with enodometrial adenocarcinoma and LGSIL|
|†1 with AIS and HGSIL|
|‡3 with AIS and HGSIL|