Clinicopathological Significance of CADM4 Expression in Invasive Ductal Carcinoma of the Breast
Jongmin Sim, Hulin Han, Seung Sam Paik. College of Medicine, Hanyang University, Seoul, Republic of Korea
Background: Cell adhesion molecule 4 (CADM4) is a novel tumor suppressor involved in cell adhesion. It has been suggested that the loss or decreased expression of CADM4 is associated with the development of some cancers. However, the CADM4 expression in breast cancer has not been investigated. The purpose of this study was to investigate the clinocopathological significance of CADM4 expression in breast cancer.
Design: We used the tissue microarrays consisting of 45 cases of ductal carcinoma in situ (DCIS) and 256 cases of invasive ductal carcinoma (IDC). We evaluated CADM4 expression in the tissue microarrays by immunohistochemistry, reviewed the patients' medical records, and performed an adjustment of the clinicopathological data with a statistical analysis.
Results: CADM4 was expressed in 37 of 45 DCIS cases (82.2%) and 173 of 256 IDC cases (67.6%). The expression rate of CADM4 was significantly higher in DCIS than IDC (p = 0.049). Loss or decrease of CADM4 expression was strongly correlated with higher histologic grade (p = 0.020), absence of estrogen receptor (p < 0.001), absence of progesterone receptor (p = 0.024), and overexpression of c-erbB-2 (p = 0.018). In univariable and multivariable Cox regression analyses for all 256 IDC cases, CADM4 expression was not significantly associated with overall and disease-free survival. However, CADM4 expression showed a significant positive association with longer disease-free survival in 187 cases of early stage IDC (p = 0.039, log-rank test).
Conclusions: Loss or decrease of CADM4 expression seems to play an important role in breast cancer progression, especially related to the invasiveness, and its aggressive biological behavior. CADM4 can be applied to a novel predicting marker for recurrence possibility or outcome of disease in an early stage IDC.
Monday, March 4, 2013 1:00 PM
Poster Session II # 61, Monday Afternoon