Loss of Heterozygosity (LOH) at 17p13 and 22q13 Is Associated with Metastasis and Shared by Breast and Thyroid Carcinomas
Bing Zhu, Sydney D Finkelstein, Jan F Silverman, Stephen M Rohan, Xiaoqi Lin. Northwestern University, Chicago, IL; RedPath Integrated Pathology, Inc., Chicago, IL; Allegheny General Hospital, Chicago, IL
Background: Our previous studies have revealed that LOHs at a few specific chromosomal loci are involved in metastasis of breast ductal carcinoma (BDC) and papillary thyroid carcinoma (PTC). In this study, we compared the patterns of LOH involved in metastasis of BDC and PTC.
Design: We retrieved 14 BDC cases with known metastasis and 19 BDC cases without metastasis as well as 12 PTC cases with metastasis and 14 cases without metastasis. Analysis of 17 polymorphic microsatellite repeat markers (PMRM) targeting 1p34-36, 3p24-26, 5q23, 9p21, 10q23, 17p13, 17q12, 17q21, 21q22, and 22q13 was performed on DNA isolated from primary tumors.
Results: See Table 1 and 2.
|Chromosome||PMRM||+ Metastasis*||- Metastasis*||P Value|
|Chromosome||+ Metastasis||- Metastasis||P Value|