Ocular Infections, Diversity of Microorganisms and Clinical Associations
Mojgan Hosseini, Jerome Taxy, Vera Tesic. University of Chicago, Chicago, IL
Background: Infectious eye disease remains a significant cause of secondary blindness in the United States. Infectious keratitis alone is associated with a 35% risk of secondary blindness. Progression to endophthalmitis requiring enucleation is uncommon in the absence of comorbid conditions. This survey of patients with sight-threatening ophthalmic infections identifies the causative organisms and outcomes.
Design: Ophthalmic microbiology results were reviewed on patients with positive cultures from corneal and intraocular specimens over the period 2007-2012; 347 organisms were identified from 167 patients.
Results: The most commonly identified organisms in the studied population are listed in Table 1. The most common organisms were distributed over a range. In contact lens wearers, Pseudomonas aeruginosa (24%) was the most common isolated organism. In addition rare fungi, i.e. Aspergillus spp. (6 cases), Candida spp. (3 cases), and the protozoan, Acanthamoeba, were isolated (4 cases). 24 enucleations and eviscerations were identified, three of which had positive cultures for coagulase negative Staphylococcus, Corynebacterium and Pseudomonas aeruginosa. Predisposing factors included a history of trauma and corneal ulcers (45%), previous ophthalmic surgery (26%) and systemic diseases such as diabetes mellitus and sarcoidosis (20%).
|Coagulase negative Staphylococcus||34%|
|Methicillin sensitive Staphylococcus aureus||7%|
|Methicillin resistant Staphylococcus aureus||4.8%|