Leukemia and Lymphoma-Associated Crescentic Glomerulonephritis
Mei Lin Z Bissonnette, Anthony Chang, Shane Meehan. University of Chicago, Chicago, IL
Background: A variety of glomerulopathies have been reported in association with hematologic diseases. Reports of crescentic glomerulonephritis (GN) occurring concurrently with hematologic malignancies are rare. We present a series of 3 cases of crescentic GN associated with leukemias and lymphomas.
Design: The clinical and pathologic data of 3 patients with hematologic malignancies and kidney biopsies showing crescentic GN were retrospectively reviewed. Biopsies were obtained between 2009 and 2011.
Results: The three cases of crescentic GN associted with leukemias and lymphoma are summarized in Table 1.
|Case Number||Age/Sex||Malignancy||SCr (mg/dL)||Kidney Biopsy||Serology||Outcome (After Biopsy)|
|1||48/F||Natural killer (NK) cell leukemia||2.4||Focal crescentic GN, pauci-immune||ANCA negative||DOD in 2 months|
|2||85/M||Angioimmunoblastic T cell lymphoma (AITL)||4.6||Focal crescentic GN, with linear IgG||ANCA negative, Anti-GBM negative||DOD in 5 months|
|3||74/F||B cell chronic lymphocytic leukemia (CLL)||N/A||Diffuse crescentic GN, with linear IgG||N/A||DOD in 9 months|