Synoptic Report Generators for Molecular and Ancillary Test Reporting in Anatomic Pathology Laboratory Information System (APLIS)
Ahmad Alkhasawneh, Bernadette Harris, Hui-Jia Dong, Robert W Allan. University of Florida, Gainesville, FL
Background: Synoptic reporting for cancer has increased the consistency, completeness of reporting, ease of interpretation and enabled searchable results. Many of these are done using embedded synoptic report generators that allow for check box or short field reporting. We sought to develop a similar system for reporting of molecular tests and ancillary tests using a custom-built embedded synoptic report generator in our anatomic pathology laboratory information system(APLIS) (PowerPath™, SunQuest).
Design: We built and implemented custom synoptic reporting- based embedded templates using the worksheet function within our APLIS (PowerPath™) for the different molecular and specialized ancillary tests. Molecular tests included a comprehensive lung cancer (EGFR, ALK, KRAS, BRAF), colon carcinoma reporting templates (KRAS, Microsatellite instability (MSI), BRAF, MSI immunohistochemistry) and T- and B- cell clonality. Ancillary tests included breast carcinoma comprehensive reporting template (ER, PR, HER2 IHC, and HER2 FISH) and UroVysion™ reporting templates.
Results: The embedded worksheet reports had the following advantages of standard reporting: 1) Ability to generate a summary results section at the top of report; 2) ease of reporting with standardization of the reporting; 3) ability to generator specific comments specific to prognosis and implications for therapy for a particular mutation (EGFR, KRAS mutation); 3) generation of quality assurance reports such as rates of positivity for mutations, rate of ER/PR/HER expression relative to degree of differentiation of tumor, correlation of cytology with UroVysion™ findings; 4) creation of a searchable database for items such as all particular mutations and ER/PR/HER2 expression; 5) ability to incorporate free text comment sections for needed flexibility.
Conclusions: Embedded synoptic report generators for molecular and ancillary reporting within an APLIS has improved consistency, accuracy, ease of reporting and interpretation and allowed for easier quality assurance tracking and research applications.
Wednesday, March 6, 2013 1:00 PM
Poster Session VI # 258, Wednesday Afternoon