Fibroadenomatous Lesions in Pediatric Age Group
Sara Faiz, Vladislav Tudor, Gokmen-Polar Yasim, Sunil Badve. Indiana University School of Medicine, Indianapolis, IN
Background: Fibroadenomatous lesions (FAs) are well described in adults but the morphological features are poorly characterized in the pediatric age group (age<18). We investigated the morphological features of FAs in this age group.
Design: From January 1999 to December 2011, 119 cases with the diagnosis of fibroadenoma in females age 18 years or younger were identified and were reviewed by two pathologists. FAs were divided into different groups based on their morphological appearance into tubular (epithelial rich), classic, cellular (increased stromal cellularity), juvenile (epithelial hyperplasia), and mixed types and phyllodes tumor (stromal overgrowth) on the basic of predetermine criteria.
|Type of Fibroadenoma||Tubular n= 18||Cellular n=12||Classic n=62||Juvenile n=18||Tub&Classic n=5||Phyllodes n=4|
|Mean Age ( yrs)||16||15||16||14||15||16|
|Sclerosing Adenosis (Y/N)||0/18||0/12||0/62||0/18||0/5||0/4|
|Mitosis/10hpf||≤1=16, ≤3=1, ≤5=1||≤1=8, ≤2=4<||≤1=56, ≤3=6||≤1=11, ≤3=5, ≤5=2||≤1=5||≤5=4|
|Increase periductal cellularity (Y/N)||10/8||5/7||35/27||17/1||3/2||4/0|
|Ratio of stroma to epithelium||<1=18||<1=4, 1=6, >1=2||<1=2, 1=57,>1=3||<1=2, 1=10, >1=3||<1=2, 1=3||>1=4|
|Intracanalicular (I), pericanalicular (P)||P13, I+P=5||P=4, I=2, I+P=6||P=7, I=23,I+P=32||P=4, I=2, I+P=12||P=2, I+P=3||I+P=4|
|Periepithelial infitrate (Y/N)||6/12||3/9||9/53||6/12||1/2||2/2|
|Types of stroma[ Fibrous=F, Periductal and fibrous interductal=PFIND, Hyaline=H, Myxoid=M]||F=12, PFIND=6||F=7,PFIND=3, H=1, M=1||F=4, M=16, PFIND=42||F=6, M=1, PFIND=11||F=3, PFIND=2||F=4|