Risk Factors in Patients with Low-Grade Endometrial Adenocarcinoma and Lung Recurrence Versus Recurrence at Other Sites. A Multi-Institutional Study
Andres A Roma, Denise A Barbuto, Elizabeth Euscher, Rouba Ali-Fehmi, Bojana Djordjevic, Jennifer A Bennett, Elizabeth E Frauenhoffer, Sun Rang Hong, Insun Kim, Delia Montiel, Elizabeth Moschiano, Anais Malpica, Elvio G Silva. Cleveland Clinic, Cleveland, OH; Cedar Sinai, Los Angeles, CA; MD Anderson, Houston, TX; Wayne State University, Detroit, MI; Ottawa Hospital, Ottawa, ON, Canada; Penn State University, Hershey, PA; Cheil General Hospital, Seoul, Korea; Instituto Nacional Cancerologia, Mexico, Mexico
Background: There is no significant data analyzing risk factors for low-grade endometrial tumors that recur in the lung vs other sites.
Design: In this multi-institutional study, we analyzed data from 79 patients with FIGO grade 1 and 2 endometrial adenocarcinomas with extrauterine recurrence (excluding vagina) and 187 age matched controls with negative lymph nodes and no treatment that did not recur; with similar follow-up time (44 and 59 months, respectively).
Results: Twenty patients had lung recurrence and 59 patients had recurrence in other sites at initial recurrence (Table 1). Tumors that recurred in lung showed a significantly greater depth of myometrial invasion, compared to other recurrences (p<0.05) and controls (p<0.0001), respectively. Cervical involvement was more frequent in cases with lung recurrence than in other sites (p< 0.05); moreover, cervical stromal involvement was a highly significant risk factor (p<0.003) for lung recurrence. All analyzed features, except necrosis, were significantly different in all recurrent tumors compared to controls (p<0.001).
|Lung (20)||Flat 8/Exo 11/Unk 1||4.9||9||61.2% (12 >50%;3>33%)||10 (25.3%)||17||13 (10 stroma)|
|Other rec (59)||Flat 20/Exo 36/Unk 3||5.1||34||44.1% (24>50%;8>33%)||31 (18.2%)||38||23 (13 stroma)|
|Controls (187)||Flat 49/Exo 138||3.3||73||26.9% (41>50%;22>33%)||61 (10.2%)||80||15 (11 stroma)|