Mucinous Ovarian Tumors in Childhood – An Institutional Experience
Rong Fan. Indiana University, Indianapolis, IN
Background: Mucinous tumors of the ovary are primarily diagnosed in middle aged and elder woman and they are very rare in first two decades of life and exceedingly rare in premenarchal girls.
Design: We reviewed our institutional pathology files in the past 20 years and retrieved 15 cases of primary mucinous tumors of the ovary.
Results: Their clinical pathological profiles are as follows: Age range was 6-19 years, average 12.1 years; 4 patients were definitely premenarchal at the age of presentation, 6 of them better be grouped as peri-menarchal and rest of the 5 patients were post-menarchal adolescents. The tumor size ranged from 3.5 to 32 cm, average 14.3 cm The majority (9 cases) of the case were multiloculate but significant portions were unilocular and bilocular (3 cases each) 8 cases happened in the right side, 6 cases left and 1 case bilateral. The majority of the cases were mucinous cystadenoma (10 cases); 3 cases were mixed mucinous and serous cystadenoma and 2 cases qualified for borderline mucinous tumors. All of them presented as stage I tumor and behaved in benign fashion on follow-ups. There was no malignant cases in our study except one case of metastatic mucinous adenocarcinoma from colon origin which was excluded from the total number. Of histology subtypes, majority of them were lined by endocervical type epithelium and minority of them were lined by intestinal type endothelium. Depending on the cutoff criteria, certain proportions of cases showed mixed types lining epithelium. All the clinical suspicious cases were tested with serum tumor markers and were negative. The composite picture shows an 18.5 cm multiloculated mucinous cystadenoma from a 13 year old.
Conclusions: Mucinous tumors in childhood share the some same clinical characteristics as they are in the adult population- large size, expansile and mostly multilocular growth pattern. However, in the pediatric population, all of the cases followed behaved in a benign fashion including the ones with borderline features. Mucinous tumors of ovary can certainly happen in premenarchal girls and this group was perhaps under-reported in the medical literature. Common tumor markers (alpha-fetoprotein, CA-125 and beta HCG) are useful for preoperative predication.
Category: Gynecologic & Obstetrics
Wednesday, March 6, 2013 9:30 AM
Poster Session V # 171, Wednesday Morning