Invasive Carcinoma of Breast Morphology and Immunohistochemical Classification – King Abdulaziz University Hospital Experience
Fadwa J Altaf, Eman AS Emam, Ghadeer A Mokhtar, Rana Y Bokhary, Lamya A Baharith, Hiba H Ali, Zuhoor K Al- Gaithy. King Abdulaziz University, Jeddah, Western, Saudi Arabia
Background: Management and prognosis of Invasive breast carcinoma (IBC) does not depend any more on pure morphology only, but it also includes the Immunohistochemical features of the tumor based on its content of Estrogen Receptors(ER),Progesterone Receptors(PR),and HER 2 Receptors (HER2). Large numbers of studies publish the new classification based on Immunostains and molecular findings.
Design: A retrospective study is designed to reclassify cases of invasive breast carcinoma received and diagnosed at Anatomical pathology of king Abdulaziz University hospital.We identified 155 cases that fit our inclusion criteria.Patient's age were recorded. We classify them histologically into,invasive ductal carcinoma not otherwise specified(IDCNOS), pure special type (PST) and mixed type (MT).Tumor size was identified, grade was applied to all of the three groups. In addition certain immunohistochemical markers including ER,PR,HER2, P63, Ki67 and other when necessary were applied.
Results: We identify 7 groups (G), Luminal A(ER+,PR+&HER2-). Lumina B (ER+,PR+&HER2+). While HER2+(ER-,PR-&HER2+) & triple negative (ER-,PR-&HER2-). We also have apparent groups(AG 5&6) of Luminal A&B that they lack PR positivity. Apparent HER2+(G7) that lack ER+. Majority of cases 59% are presented between 41-60 years of age, while 13% were below the age of 40yrs. All of our cases were presented with large tumor sizeT2&T3.(Table 1)
|Group 1 LuminalA||3.25||58||37,4%||g1=19,g2=32,g3=7||42||10||6|
|Group 2 LuminalB||3.62||24||15.5%||g1=6,g2=16,g3=2||18||3||3|
|Group 3 HER+||3.88||17||11%||g1=1,g2=10,g3=6||15||1||1|
|Group 4 Triple Negative||3.86||26||16,8%||g1=3,g2=6,g3=17||22||3||1|
|Group5 App.Luminal A||2.86||18||11.6%||g1=5,g2=12,g3=1||14||2||2|
|Group6 App.Luminal B||2.5||10||6.5%||g1=8,g2=2,g3=0||10||0||0|