p63 Imunohistochemistry in Histologic Variants of Urothelial Cell Carcinoma
Jeremy Klapper, Guang-Qian Xiao, Pamela D Unger. The Mount Sinai Medical Center, New York, NY
Background: Urothelial carcinoma (UC) occurs in a variety of histologic subtypes. p63, a member of the p53 family of transcription factors, is one of the most commonly used urothelial markers. There has been no prior systematic study regarding p63 immunohistochemical expression in histologic variants of UC.
Design: A total of 41 invasive UCs of different morphologic variants collected at our institution were stained with p63 monoclonal antibody (BioGenex, San Ramon, CA). Among the 41 UCs, 22 were of one morphologic variant and 19 contained more than one morphologic variant. For cases with more than one morphologic variant, each individual variant was counted as a separate event. In addition to p63, the two plasmacytoid UC cases were also stained with CD138 antibody (BioGenex, San Ramon, CA). Positive immunostaining was defined as uniform nuclear reactivity for p63 and cytoplasmic membrane staining for CD138.
Results: The results of p63 immunostaining are summarized in the table.
|Histologic Variant||p63 positive cases/Total cases|