SOX10 Expression in Malignant Melanoma, Carcinomas, and Normal Tissues
Amr Rashed, Raul Gonzalez, Diane Lawson, Jason Wang, Cynthia Cohen. Emory University Hospital, Atlanta, GA
Background: SOX10 (Sry-related HMg-Box gene 10) is a nuclear transcription factor that plays an important role in melanocytic cell differentiation. It has been shown to be a sensitive marker of melanoma including spindle and desmoplastic subtypes. We assessed its expression in melanomas, carcinomas and benign tissues.
Design: In order to assess sensitivity and specificity, we studied melanomas, carcinomas, benign nevi, and normal tissues in tissue microarrays with routine immunohistochemistry for SOX10.
Results: All melanomas were strongly and diffusely nuclear SOX10-positive.They included 2 spindle cell, 1 desmoplastic and 2 in situ melanomas.
|Type of tissue||Number of Cases||Sox10 Positive number/Percent|
|Normal tissues||Number of Cases||Sox10 Positive number/Percent|