Solid Pseudopapillary Tumor of the Pancreas: Spectrum of Clinical Presentations and Morphologic Variants
Po Zhao, Pedro deBrito, Mary K Sidawy. Georgetown University Hospital, Washington, DC
Background: Solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm predominantly seen in young women. It typically presents as a large tumor with cystic and solid components. The major differential diagnosis includes pancreatic endocrine tumor (PEN). This study presents our experience with this tumor with emphasis on two morphologic variants: SPT with signet ring cells, and SPT with clear cells.
Design: Fifteen histologically confirmed SPT were identified in our files. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) was performed in 8/15 cases. Patients' demographics, cytohistologic correlation and tumor characteristics were evaluated.
Results: The results are summarized in the table.
|Age (yr)||Sex||Site||Size (cm)||FNA Dx||Gross|
|36||F||Body/tail||2.3||SPT vs. PEN||Solid|
|27||M||Body/tail||3.6||Malignant with signet ring features||Solid|
|55||F||Body/tail||3.5||SPT vs. PEN||Cystic|
|50||F||Body/tail||8.5||SPT||Solid & cystic|
|25||F||Body/tail||2||SPT with vacuolated cells||Solid & cystic|