Follow-Up Outcomes of a Large Cohort of Low-Risk Patients with Negative Imaged Liquid-Based Cytology and Negative HPV Test Results
Baoying Weng, Marshall R Austin, Zaibo Li, Huaitao Yang, Mona Bansal, Chengquan Zhao. Magee-Womens Hospital, UPMC, Pittsburgh, PA; Conemaugh Valley Memorial Hospital, Johnstown, PA
Background: Concurrent testing for HPV and cytology (co-testing) is an FDA-approved cervical screening alternative for women 30 years and older. The objective of this study was to document the development of significant cervical disease over time in a large cohort of low risk women with “double-negative” co-test results.
Design: The CoPath database was searched from July 2005 to June 2006 to retrieve cases with both negative hrHPV and cytology results. hrHPV testing used the HC2 assay. Pap tests were LBC ThinPrep specimens screened utilizing computer-assisted screening. Pap, histologic, and repeat HPV test follow-up results were recorded and analyzed.
Results: Double-negative cotest results were identified in 4112 women, and 3211 had recorded histopathologic and/or cytological follow-up results. The average age of the women was 46.8 years (15-87). The average follow-up period was 44 months (1-69). Histopathologic and cytologic follow-up results are shown in Table 1.
|Follow-upMethod(s)||Total Case#||Glandular neoplasia*||CIN2/3/HSIL#||CIN1/LSIL||CIN/SIL|
|Histology||549||6||5 (0.9)||50 (9.1)||55 (10.0)|
|Cytology only||2662||0||1 (0.04)||24 (0.9)||25 (0.9)|
|Total||3211||6 (0.2)||6 (0.2)||74 (2.3)||80 (2.5)|
|HPV testing||Case No||%|
|Both positive and negative||51||2.5|