Nuclear Pseudo-Inclusions Are Rare, but Nuclear Grooves Are Nearly Always Present, in Cytopathology and Histopathology Material of Encapsulated Follicular Variant of Papillary Thyroid Carcinoma
Florence Loo, Andrew Schreiner, Theresa Scognamiglio, Syed Hoda, Rana Hoda. Weill Medical College of Cornell University, New York, NY
Background: Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (EFV-PTC) can be diagnostically challenging in cytopathology as well as histopathology material; mainly because its nuclear features can often be focal and subtle; and remain, thus far, a diagnostic challenge.
Design: All archived histopathology slides from surgically-resected EFV-PTC cases (2006-2011) were retrieved. Diagnosis was confirmed (Mod Pathol 2011;24:S1-S9, Acta Cytol 2002;46:555-561). Corresponding fine needle aspiration (FNA) cytopathology preparations (Diff-Quik and/or Pap) were retrieved. Consensus review (2 observers) was undertaken of all histopathology and cytopathology material, particularly with regards to nuclear features.
Results: Table 1 shows the results of the nuclear features based on the aforementioned review.
|Grooves||19/20 (95%)||20/20 (100%) *|
|Elongation||19/20 (95%)||20/20 (100%)|
|Overlap||19/20 (95%)||20/20 (100%)|
|Ground Glass||18/20 (90%) **||20/20 (100%)|
|Irregular Shape||17/20 (85%)||20/20 (100%)|
|Pseudo-inclusions||02/20 (10%)||01/20 (5%) ***|