Diagnostic Utility of Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Review of 593 Cases
Arivarasan Karunamurthy, Guoping Cai, Sanja Dacic, Walid E Khalbuss, Liron Pantanowitz, Sara E Monaco. University of Pittsburgh Medical Center, Pittsburgh, PA; Yale University School of Medicine, New Haven, CT
Background: Establishing a definitive and accurate diagnosis is important for the diagnosis of mediastinal lesions by endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) and can decrease the need for additional diagnostic work up. Our aim was to evaluate the diagnostic utility of EBUS-FNAs from our institution.
Design: A retrospective review of all EBUS-FNA biopsies procured at our institution over a three year period (2007 to 2010) was performed to look at the adequacy, cytological diagnosis, and the available histological follow-up. Cases were given an adequacy statement (satisfactory/SAT, less than optimal/LTO, or unsatisfactory/UNSAT) and a descriptive diagnosis at the time of final cytological diagnosis that was based on cytomorphology and in some cases ancillary study results. Indeterminate cases were those cases with a final diagnosis of atypical or suspicious.
Results: A total of 593 EBUS FNA specimens were obtained from 357 patients with a mean age of 61years (ranging from 23-90 years), including 420 SAT cases (71%), 107 LTO cases (18%) and 66 UNSAT cases (11%). Histological follow-up was available in 203 cases (34.2%).
|FNA adequacy & diagnosis||Histology: Benign||Histology: Granulomas||Histology: Neoplasm||Histology: Malignant||TOTAL|