Frequency and Etiology of Unsatisfactory Cervical Cytology by ThinPrep® Method in a Tertiary Care Urban Setting – A Snapshot of Brief Duration
Tatyana Kalinicheva, Neelofur Nazeer, LaQuita King, Tamar Giorgadze, Sudeshna Bandyopadhyay, Shashi Madan, Dongping Shi, Vinod Shidham. Detroit Medical Center and Wayne State University School of Medicine, Detroit, MI
Background: The rate of unsatisfactory cervical cytological specimens is usually higher (up to 3.5%) for ThinPrep® preparation (TP) as compared to the conventional or SurePath™ preparations.
Design: We studied 7,644 cervical cytology specimens (ages 13 to 84, mean- 38 years) over a brief period of 6 weeks for unsatisfactory TP preparations submitted to our tertiary care center with annual turnover of more than 80,000 cervical specimens. Out of these, 233 (3.1%) specimens were interpreted as unsatisfactory. We analyzed various etiologic factors responsible for unsatisfactory interpretation in these specimens.
Results: Several causes for inadequate interpretations were identified (Table 1).
|Causes||Number of specimens (Total 233)||(%)|
|LUBE & blood||40||17|
|LUBE & inflammation||9||4|
|LUBE, blood, & inflammation||2||1|
|LUBE & ACC||20||9|
|LUBE, ACC, & inflammation||1||1|
|ACC with inflammation (atrophic vaginitis)||4||2|
|Blood & Inflammation||4||2|
|Inflammation with scant squamous cells||1||1|
|Scant squamous cells||22||9|
|Other (e.g. cell clumping without particular reason)||2||1|