[1822] An Autopsy Study of Fatal Febrile Encephalopathy

Rakesh Kumar Vasishta, Sandeep Kumar, Nandita Kakkar, Kirti Gupta, Ashish Bhalla, Pratibha D Singhi. Post Graduate Institute of Medical Education and Research, Chandigarh, UT, India

Background: Febrile encephalopathy is a term used to denote patients presenting with fever and altered mentation. It is a common condition leading to emergency admissions in both adults and children in India. The profile of acute febrile encephalopathy varies across different geographic regions with newer agents being increasingly recognized all over the world. This study is aimed at knowing the etiology in fatal cases presenting clinically as “febrile encephalopathy”.
Design: All adult and pediatric cases autopsied in the Department of Histopathology, PGIMER with the clinical diagnosis of febrile encephalopathy over a period of 14 years (1996-2010) were analyzed.
Results: A total of 80 autopsy cases were analyzed. Viral encephalitis (41/80 cases i.e. 51%) was the commonest cause of febrile encephalopathy with Japanese encephalitis accounting for 65.8% (27 of 41 cases) of all viral encephalitis in this study. This was followed by bacterial meningitis in 10 cases (13%) of which 7 were tubercular and 3 pyogenic. Other causes documented were cerebral venous thrombosis (3), cerebral malaria (2), acute haemorrhagic leucoencephalitis (2), primary amoebic meningoencephalitis (1) and Leigh's syndrome (1). Non specific changes were seen in 20/80 i.e. in 25 % of the cases.
Conclusions: Viral encephalitis of which majority of cases were of Japanese encephalitis is the commonest cause of febrile encephalopathy in this study. Non specific changes are seen in a substantial number i.e. 25 % of the cases of febrile encephalopathy.
Category: Neuropathology

Tuesday, March 20, 2012 1:00 PM

Poster Session IV # 277, Tuesday Afternoon


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