Central Nervous System Involvement by Myeloid Sarcoma
Adriana Olar, Thor D Stein, Christian J Davidson, Arie Perry, Gabriela Gheorghe. The Methodist Hospital, Houston, TX; Boston VA Medical Center, Boston University School of Medicine, Jamaica Plain, MA; Massachusetts General Hospital, Harvard Medical School, Boston, MA; Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI; University of California, San Francisco, San Francisco, CA
Background: Myeloid sarcoma (MS) is an extramedullary hematopoietic neoplasm of myeloid origin. Central nervous system (CNS) involvement by MS is unusual. We report ten cases of biopsy-proven CNS MS.
Design: The pathology records across eight institutions were searched for CNS MS. The clinical course, radiology and pathology were reviewed.
Results: Our results are summarized below.
|#||Age y/Sex||Associated hematologic neoplasia||Cytogenetics||CNS involvement||Other sites of involvement||CSF||Survival/mo|
|1||0.5/M||AML||Trisomy 8||L FP||-||+||AWD/12|
|5||48/F||CML||t(9:22)||R S1-S2 foramina||R sacrum||N/A||D/2|
|6||53/M||N/A||N/A||Multiple cervical and thoracic spinal cord roots||Cervical and thoracic paraspinal soft tissue||N/A||A|
|7||64/M||AML||5q del||T6-T9 bilateral neural foramina and epidural space||T6-T9 paraspinal soft tissue||N/A||D/4|
|8||69/F||PV||Complex; JAK2 mutation||L F dura||-||+||D/3|
|9||76/M||MDS||Trisomy 21||Choroid plexus, pituitary||Widespread||N/A||D/8|