Human Herpesvirus Type 8 in Patients with Child-Pugh Class A to C Cirrhosis
Cheng-Chuan Su, Ming-Nan Lin, Kuo-Chih Tseng. Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan; Tzu Chi University, Hualien, Taiwan
Background: Human herpesvirus type 8 (HHV-8) DNA has been found consistently in all types of Kaposi's sarcomas (KSs). KS can develop in human immunodeficiency virus (HIV) non-infected patients with variable immunologic abnormalities. Previous studies have been found that patients with Child–Pugh class B/C cirrhosis have a significantly greater seropositive rate for HHV-8 antibodies compared with healthy controls. Those studies did not specifically exclude diabetic patients. It is well known that patients with diabetes have an increased risk of infection with opportunistic diseases and that the risk of classic KS is four-fold higher in patients with diabetes. There have been no comprehensive studies regarding patients with pure cirrhosis from Child–Pugh class A to C until to now.
Design: Cell counts and HHV-8 antibody and DNA were detected in blood samples from 108 cirrhotic patients without diabetes and 108 age- and sex-matched healthy controls.
Results: Mean lymphocyte, monocyte, and platelet counts were significantly lower, higher, and lower in Child-Pugh class C than class A cirrhotics (each P < 0.02), respectively. Monocyte counts were significantly greater in male and class B cirrhotics than female and class A or C cirrhotics (each P < 0.05), respectively. Hepatitis C virus (HCV)-infected cirrhotics had significantly lower lymphocyte and platelet counts than alcoholic patients and hepatitis B virus (HBV) infected or alcoholic patients (each P < 0.05), respectively. Seropositive rates and titers for HHV-8 antibodies were significantly greater in patients, particularly male and class B or C or HCV-infected cirrhotics, than the controls (each P < 0.0001). Seropositive female patients were significantly older than seropositive male patients (P = 0.0130), respectively. The rates and titers were also significantly greater in class B or C than class A cirrhotics (each P < 0.05). One HCV-infected male patient was positive for HHV-8 DNA (98 copies/mL).
Conclusions: Lymphopenia, monocytosis, and thrombocytopenia and seropositive rates and titers for HHV-8 antibodies were significantly greater in advanced versus mild cirrhotics. Monocytes increased, boosted, and then significantly decreased with Child-Pugh classes.
Wednesday, March 21, 2012 1:00 PM
Poster Session VI # 254, Wednesday Afternoon