Glycolytic Phenotype is Correlated with Aggressiveness and Worse Prognosis in Invasive Ductal Carcinomas
Hulin Han, Se Min Jang, Ki-Seok Jang, Young Jin Jun, You Na Oh, Min Sung Chung, Seung Sam Paik. College of Medicine, Hanyang University, Seoul, Korea
Background: Glucose uptake and glycolytic metabolism are enhanced in cancer cells and increased expression of GLUT1 has been reported in human malignancies. The aim of this study was to investigate GLUT1 expression in human breast tissuesand its correlation with various clinicopathological parameters, as well as its effect on patient survival in invasive ductal carcinomas.
Design: We used tissue microarrays consisting of normal breast tissue (18 cases), ductal hyperplasia (14 cases), ductal carcinoma in situ (55 cases), invasive ductal carcinoma (276 cases), and lymph node metastasis (58 cases). Immunohistochemistry was used and review of medical records and clinicopathological analysis were performed.
Results: Membranous GLUT1expression was observed in normal and tumor cells. GLUT1 expression was markedly increased in ductal carcinoma in situ, invasive ductal carcinoma, and lymph node metastasis than normal and ductal hyperplasia. In invasive ductal carcinomas, 106 (38.4%) of 276 cases showed GLUT1 expression. GLUT1 expression was correlated with higher histologic grade (p< 0.001), larger tumor size (p= 0.025), absence of estrogen receptor (p< 0.001), absence of progesterone receptor (p< 0.001), and triple-negative phenotype (p< 0.001). In univariate survival analysis, patients with GLUT1 expression revealed poorer overall survival and disease-free survival (p = 0.017 and p = 0.021, respectively, log-rank test). In multivariate survival analysis with the Cox proportional hazards model, GLUT1 expression was an independent prognostic factor of overall survival and disease-freesurvival (p = 0.017 and p = 0.019, respectively).
Conclusions: Our results demonstrated that GLUT1 expression may play an important role in the malignant transformation anda glycolytic phenotype can be a marker of aggressive biologic behavior and a worse prognostic factor in invasive ductal carcinomas.
Wednesday, March 21, 2012 9:30 AM
Poster Session V # 35, Wednesday Morning