Myeloid Neoplasia with t(3;8)(q26;q24): Report of Four Cases and Review of the English Literature
Xiangdong Xu, Mu Su, Norman B Levy, Prabhjot Kaur, Rolando Garcia, Arash Mohtashamian, H Elizabeth Broome, Maria L Dell'Aquila, Huan-You Wang. Univ. of California San Diego, La Jolla, CA; Univ. of Texas Southwestern Medical Center, Dallas, TX; Dartmonth-Hitchcook Medical Center, Lebanon, NH; Naval Medical Center San Diego, San Diego, CA
Background: t(3;8)(q26;q24) is an extremely rare nonrandom balanced chromosomal translocation accounting for 3.5% of myeloid malignancies with 3q rearrangements. There are only 11 cases reported to date in the English literature. To better characterize this rare translocation, we report 4 additional cases of myeloid neoplasm with t(3;8)(q26;q24).
Design: Cytogenetic databases from three institutions were searched and four cases with t(3;8)(q26;q24) [2 acute myeloid leukemia (AML) and 2 myelodysplastic syndrome (MDS)] were retrieved.
Results: Three of the four patients were male, with ages ranging from 41 to 84 years old. One patient (#2) was positive for HIV, Kaposi sarcoma, and had a 9-year history of granulocyte colony stimulating factor (G-CSF) treatment for neutropenia. None of the patients had a history of chemotherapy prior to the current diagnosis.
Two (#1, #4) of the patients were initially diagnosed with AML and two (#2, #3) with MDS. The peripheral blood in all patients showed moderate anemia and variable levels of thrombocytopenia; one patient also had absolute neutropenia (#2). The bone marrows exhibited trilineage dysplasia in two patients (#1, #4) and erythroid and megakaryocytic dysplasia in the remaining two patients (#2, #3).
Conventional Karyotyping (Table1) revealed t(3;8)(q26;q24) as the sole abnormality in two patients (#1, #2). One patient (#3) had an accompanying trisomy 14 while the fourth (#4) also displayed deletion of 7p11.2p15 as well as isochromosome 7p10. In our limited cohort of patients, we did not detect an associated monosomy 7 as previously reported.
|#4||46,XX, t(3;8)(q26.2;q24.1)/46,idem,del(7)(p11.2p15)/ 45,idem,i(7)(q10)[cp2]/46,XX |