MYB Overexpression Associated with Advanced Stage of Adenoid Cystic Carcinoma and Together with TTF-1 Identifying Rare Lung Primary Subtype
Lei Zhang, Stanley YT Loo, David Shimizu, Stacey A Honda, Ying Cao, Amy Powers, Michele Carbone. University of Hawaii, Honolulu, HI
Background: t(6,9)(q22-23;p23-24)MYB-NFIB reciprocal translocation has been recently linked to adenoid cystic carcinoma. However the relationship between the resultant MYB overexpression and clinical outcome is not clear. Besides, lung metastasis versus lung primary adenoid cystic carcinoma is occasionally a pathological diagnostic challenge.
Design: To address these questions, we examined MYB and TTF-1 protein expression in a consecutive case cohort of adenoid cystic carcinoma including 41 formalin fixed paraffin embedded specimens biopsied or surgically resected from 34 patients.
Results: The overall positivity of immunoperoxidase for MYB is 31/41 (76%). In the salivary, nasosinal, orbital and supraglottic locations, MYB is overexpress in 14/15 (93%) cases which have local recurrence, distal metastasis or TNM stage III/IV; 7/12 (58%) cases which are TNM stage I/II or of no recurrence for 7-12 years. The performances of MYB in other anatomic sites are: lung peripheral primary 5/5 (100%); lung metastasis3/3 (100%); liver metastasis 1/1, endotracheal 1/2 (50%), thyroid 0/1 and breast 0/1. In addition, TTF-1 is highly specific for adenoid cystic carcinoma of lung peripheral primary. TTF-1 is positive only in lung primary lesion 5/5 (100%), negative for lung metastasis 0/3 (0%), tracheal/thyroid origin 0/3 (0%), and all the adenoid cystic carcinoma otherwise located 0/30 (0%).
Conclusions: It seems that MYB overexpression is associated to advanced TNM stage, local recurrence and distant metastasis of adenoid cystic carcinoma of head and neck origin. TTF-1 is useful distinguishing lung primary peripheral subtype from metastatic adenoid cystic carcinoma.
Category: Head & Neck
Tuesday, March 20, 2012 1:00 PM
Poster Session IV # 159, Tuesday Afternoon