[1311] p16 Expression and Prognostic Value in Laryngeal Squamous Cell Carcinomas – A Large Cohort Study from Chinese Patients

Jennifer Leidy, Kai Chen, Thomas Stockl, Weijun Ye, Qiuliang Wu, Jianzhong Liang, Bruce Woda, Zhong Jiang. University of Massachusetts Medical School, Worcester, MA; State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, China; SunYat-sen University, Guangzhou, Guangdong, China

Background: In the United States and Europe, about 40-80% of head and neck squamous cell carcinoma are caused by human papillomavirus (HPV). p16 expression and HPV infection have been demonstrated to be a favorable biomarker for patients with head and neck squamous cell carcinoma. However, p16 expression and its prognostic value of laryngeal squamous cell carcinoma in patients from China are unknown. We aimed to investigate p16 expression and its prognostic value in Chinese patients with laryngeal squamous cell carcinoma.
Design: A total of 236 patients with laryngeal squamous cell carcinomas (laryngectomy, n=111; biopsy, n=127) obtained from the Surgical Pathology file (2000-2005), Cancer Center of SunYat-sen University, Guangzhou, People's Republic of China were examined by immunohistochemistry for p16 expression. Overall survival was measured from the date of laryngectomy or biopsy to the date of death, and was censored from the date of last follow-up. Median follow-up period was 5 years and 3 months (63 months, range 7-123 months).
Results: Table 1 provides the relevant clinical characteristics of the 236 patients with laryngeal squamous cell carcinoma and p16 expression. Only 43 of 236 (18%) laryngeal carcinomas expressed p16. Age, sex, tumor stage and grade were not associated with p16-positive status.

Clinicopathological characteristics of patients with laryngeal carcinoma
 p16-Negativep16-PostitiveP Value
 n=193n=43 
Sex   
Female4 (50%)4 (50%)0.04
Male189 (83%)39 (17%) 
Age   
Mean (SD)58 (9.9)59 (10.8)0.57
Stage   
I58 (81%)14 (19%)0.77
II59 (86%)10 (14%) 
III52 (81%)12 (19%) 
IV24 (77%)7 (23%) 
Grade   
In situ10 (91%)1 (9%)0.39
W75 (86%)12 (14%) 
M79 (79%)21 (21%) 
P29 (76%)9 (24%) 
Vital Status   
Dead64 (83%)13 (17%)0.71
Alive129 (81%)30 (19%) 


Kaplan-Meier analysis showed that the 10-year rate of overall survival was similar in patients with p16 positive tumors and patients with p16 negative tumors (31% vs. 34%; P=0.28; 95% confidence interval [CI], 0.34 to 1.37).
Conclusions: p16 expression was only found in 18% Chinese patients with laryngeal carcinomas. Unlike Caucasian patients, this large cohort study provides the first evidence that HPV positivity is not a favorable biomarker for patients with laryngeal squamous cell carcinomas in China.
Category: Head & Neck

Wednesday, March 21, 2012 9:30 AM

Poster Session V # 172, Wednesday Morning

 

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