SOX2 Amplification Is a Common Event in Sinunasal Squamous Cell and Undifferentiated Carcinomas
Friederike Goeke, Alina Franzen, Roopika Mennon, Sebastian Huss, Diana Boehm, Wenzel Vogel, Friedrich Bootz, Andreas Schroeck, Sven Perner. University Hospital Bonn, Bonn, Germany; University Hospital Cologne, Cologne, Germany
Background: Although carcinomas of the nasal cavities are known to differ significantly from other cancers of the head and neck regarding causing noxa, clinical behavior and treatment, they share histological appearance. SOX2, a transcription factor-coding gene located at 3q26.33, is known to be recurrently amplified in squamous cell carcinomas (SCCs) of the lung, esophagus, skin, penis, cervix uteri and oral cavity. The aim of our study was to assess if SOX2 amplifications also occur in different tumor entities of the paranasal sinuses.
Design: Using flourescence in-situ hybridization, we assessed for SOX2 amplification status in a cohort consisting of sinonasal SCCs (n=65), sinonasal undifferentiated carcinomas (SNUC, n=18), adenocarcinomas (n=25), and adenoid cystic carcinomas (n=18). Furthermore, we performed SOX2 immunohistochemical staining to quantify protein expression.
Results: We detected SOX2 amplifications in 36% of sinonasal SCCs, 35% of SNUCs, 9% of adenocarcinomas, but none of the adenoid cystic carcinomas. Moreover, we found that the SOX2 amplification is associated with a SOX2 protein overexpression in SCCs and SNUCs.
Conclusions: SOX2 amplification is not an organ site specific event, but is a frequent genetic alteration occuring in SCCs of various organs. Since SNUCs also harbor SOX2 amplifications in similar frequencies, we hypothesize that SNUCs may be undifferentiated SCCs.
Category: Head & Neck
Wednesday, March 21, 2012 9:30 AM
Poster Session V # 169, Wednesday Morning