EBV Prevalence in Nasopharyngeal Carcinoma
Snjezana Dogan, Simion I Chiosea. Memorial Sloan-Kettering Cancer Center, New York, NY; University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA
Background: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of multifactorial etiology, including Epstein-Barr virus (EBV) and cigarette smoking. To characterize the morphologic evolution of NPC over the last 60 years, we compared basic demographic and morphologic features and prevalence of EBV in two cohorts of NPC: those diagnosed from 1957 to 1977 and cases from 2002 to 2010.
Design: NPC cases diagnosed in non-Asian patient population from 1957 to 1977 (Group 1, N=29) and from 2002 to 2010 (Group 2, N=28) were reviewed and categorized according to WHO 2005 classification as keratinizing (K-NPC) or non-keratinizing (NK-NPC) and tested for presence of Epstein-Barr virus early RNA by in situ hybridization (EBER-ISH). All cases from Group 1 were tested for total RNA integrity.
Results: Most NPC patients in Group 1 and Group 2 were men (25/29, 86.2% and 20/28, 71.4%). The average age at presentation was similar in both cohorts (53 yrs, Group 1 and 54 yrs, Group 2). K-NPC was more frequent in Group 1 than in Group 2 (10 of 29, 34.5% vs. 3 of 28, 10.7%; odds ratio = 2.9, 95% confidence interval 0.7 – 11.6; p=0.03). Total RNA quality was acceptable in 24 of 25 cases (Group 1). Change in the predominant morphology (from K to NK) was associated with slight increase in EBER ISH positivity in Group 2 (15 of 24, 51.7%, Group 1 vs. 18 of 25, 62.3%, Group 2, p = 0.24).
Conclusions: The predominant morphologic type of NPC changed from keratinizing to non-keratinizing. Patients' gender, age at diagnosis, prevalence of EBV did not change significantly. Decrease in K-NPC over the last several decades may suggest diminished impact of non-EBV-related NPC etiologies such as smoking.
Category: Head & Neck
Tuesday, March 20, 2012 1:00 PM
Poster Session IV # 170, Tuesday Afternoon