Oncofetal Protein IMP3, a New Diagnostic Biomarker for Laryngeal Carcinoma
Kai Chen, Kristine Cornejo, Weijun Ye, Qiuliang Wu, Jianzhong Liang, Zhong Jiang. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, China; Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, China; University of Massachusetts Medical School, Worcester, MA
Background: An accurate diagnosis of laryngeal squamous cell carcinoma (LSCC) is essential for patient management. The diagnosis of LSCC, especially in superficial biopsies can present a diagnostic challenge for pathologists. The ability to diagnose LSCC would be greatly improved by the detection of a tumor-associated antigen. IMP3, an oncofetal protein plays an important role in embryogenesis and carcinogenesis of certain malignant neoplasms. The aim of this study was to investigate the expression of IMP3 in LSCC and to determine whether it can serve as a diagnostic biomarker for LSCC.
Design: A total of 227 cases (laryngectomy, n=107; biopsy, n=120) of LSCC were obtained from the surgical pathology files of a tertiary Medical Center between 2000 and 2005. The diagnoses of all the cases were confirmed by at least two pathologists.
Results: IMP3 showed strong cytoplasmic staining in 210 of 227 (93%) LSCCs. IMP3 positivity was detected in >50% of tumor cells in 156 (74%) cases, 26-50% of tumor cells in 18 (9%) cases and <25% of tumor cells in 36 (17%) cases. IMP3 expression was detected in 78 of 88 (89%) well-differentiated, 99 of 101 (98%) moderately-differentiated and 35 of 38 (92%) of poorly-differentiated LSCC. In contrast, the expression of IMP3 was undetectable in all adjacent benign squamous epithelium, including pseudoepitheliomatous hyperplasia.
Conclusions: Our findings indicate that IMP3 is a highly sensitive and specific positive biomarker for LSCC. IMP3 is highly expressed in LSCC but not in adjacent benign squamous epithelium, which suggests IMP3 may play an important role in the pathogenesis of LSCC as it has been shown to play a role in cell proliferation, invasion and migration.
Category: Head & Neck
Wednesday, March 21, 2012 9:30 AM
Poster Session V # 175, Wednesday Morning