[119] Local Recurrence of Breast Cancer in Patients with DCIS Depending of the Margin Assessment

Eugenia Colon, Joseph Carlson. Karolinska University Hospital, Stockholm, Sweden

Background: Ductal carcinoma in situ is a clonal proliferation of cells growing within the basement membrane of the breast with not evidence of invasion. This study was designed to collect follow up data on breast cancer patients with DCIS with subsequently local recurrence or no depending of margin assessment.
Design: We aimed to asses the local recurrence of DCIS recently diagnosed as DCIS in our department (2009-2010, 149 cases) and to compare the results with those previously reported over a similar period of time (2006-2007, 138 cases) depending of the margin assessment as described in the Table 1. In addition sections were reviewed to asses the outcome of the different subtypes of DCIS in association with/without LCIS, FEA, CCC. Clinical follow up was obtained from our medical records. Data was statistically analyzed using Chi-square or Fisher's exact test.
Results:

Table 1

2006-2007	(% of total cases-138)	2009-2010	(% of total cases-149)
Characteristic		Characteristic
Age (years)		Age (years)
<45	16	<45	25
>45	84	>45	75
Mammographic size		Mammographic size
0-10 mm	15	0-10 mm	22
11-25 mm	28	11-25 mm	45
>25	57	>25	33
Pathological type		Pathological type
Low	9	Low	19
Intermediate	55	Intermediate	46
High	36	High	35
Pathological size		Pathological size
0-10 mm	7	0-10 mm	15
11-25 mm	45	11-25 mm	47
>25 mm	48	>25 mm	38
Margins		Margins
Positive or <1 mm	15	Positive or <1 mm	10
Negativ with 5-10 mm	24	Negativ with 5-10 mm	27
Negativ with 11-25 mm	40	Negativ with 11-25 mm	38
Negativ >25 mm	21	Negativ >25 mm	25
Local recurrence		Local recurrence
Positive or <1 mm	39	Positive or <1 mm	41
Negativ with 5-10 mm	25	Negativ with 5-10 mm	24
Negativ with 11-25 mm	28	Negativ with 11-25 mm	23
Negativ, >25 mm	8	Negativ, >25 mm	2
Associated lesions	25	Associated lesions	39

Clinical and pathologic characteristics of evaluated cases (based on initial histological reports).
Conclusions: We conclude that the assessment of margins and the early radiographic detection improved the prediction of the amount of residual tumor. A marginal distance > 25 mm showed small number of local recurrences. In addition, population-based mammography screening with technical improvements has resulted in increased detection of lesions <10 mm.
Category: Breast

Tuesday, March 20, 2012 1:00 PM

Poster Session IV # 2, Tuesday Afternoon