HPV Infection Analysis of Concurrent Glandular and Squmaous Lesions and Adenosquamous Carcinoma of the Uterine Cervix
Yeong-Hui Kim, Yu-Deok Choi, Sung-Sun Kim, Young Kim, Jong-Hee Nam. Chonnam National University Medical School, Gwangju, Republic of Korea
Background: High-grade cervical intraepithelial neoplasm (HGCIN) is a precursor lesion of squamous cell carcinoma of the uterine cervix. CIN lesions are often found adjacent to glandular lesions of adenocarcinoma and adenocarcinoma in situ (AIS). We analyzed the human papillomavirus (HPV) infection status of concurrent glandular and HGCINs and adenosquamous carcinoma of the uterine cervix to know their histogenensis.
Design: During 8-year period 2003 to 2010, 13 surgical cases of the uterine cervical adenosquamous carcinoma and 17 cases of glandular lesions with concurrent HGCINs of the cervix (11 cases of concurrent adenocarcinoma and HGCINs, and 6 cases of concurrent AIS and HGCINs) were examined in this study. The squamous and glandular components were separately microdissected from paraffin sections using a microtome blade.
Results: Of 13 adenosquamous carcinoma cases, HPV infection was positive in 12 cases. On 12 cases, the HPV type of each adenocarcinoma and squamous cell carcinoma component demonstrated the same type. The detection types were HPV 18 of 6 cases, HPV 16 of 5 cases, and 1 case of HPV 45. On remaining one cases, HPV was not detected in both components. Among 17 cases of glandular lesions with concurrent HGCINs, same HPV type (HPV-18) was presented in only one case. On 17 cases, different HPV types were demonstrated in 13 cases. On remaining 3 cases, HPV was detected in the component of HGCINs, but not detected in the component of glandular lesions. The glandular lesions in these 3 cases are adenocarcinoma, but not AIS.
Conclusions: We showed that many concurrent glandular lesions and HGCIN are formed separately. However, according to the result that same HPV type were detected in adenosquamous carcinoma, the glandular and squamous parts of the concurrent lesions do not develop into glandular and squamous components of adenosqumous carcinoma.
Category: Gynecologic & Obstetrics
Wednesday, March 21, 2012 1:00 PM
Poster Session VI # 191, Wednesday Afternoon