[1162] Mucinous Carcinoma of the Endometrium: Multi-Institutional Clinicopathologic Study of a Series of 47 Patients

Yaser R Hussein, Kinda Hayek, Sudeshna Bandyopadhyay, Daniel S Schultz, Dongping Shi, Jun Zhou, Baraa Alosh, Adnan Munkarah, Rouba Ali-Fehmi. WSU, Detroit; Henry Ford Hospital, Detroit

Background: Mucinous Carcinoma of the Endometrium (MCE) is a rare histologic type representing less than 5% of all endometrial carcinomas. The aim of this study is to evaluate the clinicopathologic characteristics and patients' outcome of this tumor.
Design: A retrospective review of our pathology database of patients with endometrial carcinoma in two large academic centers between 1995 and 2009, was performed. To qualify as MCE, tumors should show at least 50% of mucinous differentiation, with tumor cells showing intracytoplasmic mucin. H and E slides were retrieved and reviewed (2 to 8 slides per case). Clinical and pathological variables including FIGO grade, lymphovascular invasion, lower uterine segment (LUS) involvement, lymph node status, FIGO stage, recurrence, and survival were assessed. Statistical analysis using Chi-Square test and Kaplan Meier method was performed.
Results: Forty seven patients with MCE were identified. Median age was 62 years (range 43-91). The patients' clinicopathologic characteristics are listed in Table 1.

Table 1: The clinicopathologic characteristics of the 47 patients
VariableNumber of patients (%)
FIGO gradeI29(60.3%)
 II18 (39.7%)
 III0
LUS involvement11 (23.4%)
Lymphovascular invasion6 (12.7%)
FIGO StageI36 (76.6%)
 II3 (6.4%)
 IIIA2 (4.2%)
 IIIB0
 IIIC6 (12.8%)
 IV0
Recurrence5 (10.6%)


Median follow up was 62 months (range 15-189). All patients underwent surgical staging with lymph node evaluation. Only three patients received adjuvant chemotherapy after surgery. Recurrence was seen in five patients (10.6%) (4 patients with stage III and 1 with stage II). Median time of recurrence was 13 months (range 8-30). The 5-year relapse free survival was 86.3%. On univariate analysis, predictive factors of recurrence were stage IIIC (p=<0.0001), LUS involvement (p=0.003), and grade II (p=0.001). Multivariate analysis was not attempted due to small sample size and very few events.
Conclusions: To the best of our knowledge, this study is one of the largest series of MCE. Based on our cohort, the predictive factors of recurrence are stage, grade, and LUS involvement. The outcome of patients with FIGO stage I-II MCE is excellent with surgical staging alone.
Category: Gynecologic & Obstetrics

Monday, March 19, 2012 9:30 AM

Poster Session I Stowell-Orbison/Surgical Pathology/Autopsy Awards Poster Session # 175, Monday Morning

 

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