Mucinous Carcinoma of the Endometrium: Multi-Institutional Clinicopathologic Study of a Series of 47 Patients
Yaser R Hussein, Kinda Hayek, Sudeshna Bandyopadhyay, Daniel S Schultz, Dongping Shi, Jun Zhou, Baraa Alosh, Adnan Munkarah, Rouba Ali-Fehmi. WSU, Detroit; Henry Ford Hospital, Detroit
Background: Mucinous Carcinoma of the Endometrium (MCE) is a rare histologic type representing less than 5% of all endometrial carcinomas. The aim of this study is to evaluate the clinicopathologic characteristics and patients' outcome of this tumor.
Design: A retrospective review of our pathology database of patients with endometrial carcinoma in two large academic centers between 1995 and 2009, was performed. To qualify as MCE, tumors should show at least 50% of mucinous differentiation, with tumor cells showing intracytoplasmic mucin. H and E slides were retrieved and reviewed (2 to 8 slides per case). Clinical and pathological variables including FIGO grade, lymphovascular invasion, lower uterine segment (LUS) involvement, lymph node status, FIGO stage, recurrence, and survival were assessed. Statistical analysis using Chi-Square test and Kaplan Meier method was performed.
Results: Forty seven patients with MCE were identified. Median age was 62 years (range 43-91). The patients' clinicopathologic characteristics are listed in Table 1.
|Variable||Number of patients (%)|
|LUS involvement||11 (23.4%)|
|Lymphovascular invasion||6 (12.7%)|
|FIGO Stage||I||36 (76.6%)|