Radial Margins Status Impact in Squamous Cervical Cancer Recurrence: A Considerable Prognostic Factor
Rita Canas Marques, Pedro Simoes, Isabel Santana, Antonio Gomes, Ana Francisca Jorge, Ana Felix. Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal; Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
Background: Cervical carcinoma is the third most common tumor in females and "early stage" disease is predominantly treated by surgery.
Morphological parameters are known to be associated with prognosis. Our aim was to study radial margin status in patients(pts) with cervical cancer treated by radical hysterectomy (RH).
Design: We evaluated cervical carcinomas treated by RH at our institution between 2002-2008. From the 251 cases reviewed, we retrieved all squamous cell carcinomas (SCC) and excluded 152 cases—with previous ablative cone biopsy(119); other histological type(30) and other primary location(3).
The following clinicopathological parameters were evaluated: tumor size(TS), lymph node metastases(LNM), vascular invasion(VI), thickness of invasion of cervical wall(ICW), distance to radial(RM) and vaginal(VM) margins and follow-up(FU) data. Statistical analysis was done using Fisher exact test.
Results: 99 cases with SCC were evaluated. The FU period average was 45months(1-109). At the end of FU 81pts were alive without disease; disease recurrence (DR) occurred in 10pts having 5 died of disease and 5 alive with disease. The remaining pts were lost for FU(6) or died of other cause(2). The results of the clinicopathological parameters are presented in table 1.
|Parameters||with DR||without DR||p value|