Histopathologic Features of Preoperative Transurethral Prostatic Urethral Biopsy Specimens in Patients with Bladder Cancer.
Steven S Shen, Jae Y Ro, Alberto G Ayala. The Methodist Hospital and Weill Medical College of Cornell University, Houston
Background: The finding of prostatic involvement by urothelial carcinoma (UCa) preoperatively is very important for surgical planning especially the decision to do a radical cystectomy. Although transurethral biopsy of the prostatic urethra is commonly performed for patients with bladder cancer, the histopathologic findings of prostatic urethra have not been well characterized. This study summarizes the results of histopathologic features of large series of consecutive prostatic urethra biopsies.
Design: Preoperative prostatic urethral biopsies were performed at 5:00-7:00 o'clock along the prostatic verumontanum. A total of 241 preoperative prostatic urethra biopsies (1988-2009) were reviewed. The histopathologic features were evaluated and summarized.
Results: Prostatic involvement of UCa was identified in 64 of 241 (26.6%) consecutive prostatic urethra biopsy specimens: 41 (64%) of these were urothelial carcinoma in-situ and 23 (36%) were invasive UCa. Prostatic adenocarcinoma was identified in 3 patients, 2 of which were ductal (endometroid) types and 1 were acinar adenocarcinoma. Other lesions identified were one each of urethral low grade non-invasive papillary urothelial carcinoma, nephrogenic adenoma, and prostatic urethral polyp.
Conclusions: Prostatic involvement by UCa is a common finding in patients with bladder cancer. Using the appropriate sampling strategy, the biopsy can detect the majority of the prostatic involvement by UCa. In addition, incidental prostate adenocarcinomas, low grade urothelial carcinoma and benign lesions such as nephrogenic adenoma and prostatic urethral polyp may also be identified.
Category: Genitourinary (including renal tumors)
Tuesday, March 1, 2011 9:30 AM
Poster Session III # 194, Tuesday Morning