Human Papillomavirus and Non-Muscle Invasive Urothelial Bladder Cancer: Potential Relationship from a Pilot Study.
Gabriella Nesi, Tommaso Cai, Sandra Mazzoli, Pierangelo Geppetti, Riccardo Bartoletti. University of Florence, Italy; Santa Chiara Hospital, Trento, Italy; Santa Maria Annunziata Hospital, Florence, Italy
Background: Although the association between High-Risk Human Papilloma Viruses (HR-HPV) and urothelial bladder carcinoma has been extensively investigated, data on the role of HPV in bladder carcinogenesis are controversial. The aim of the present study was to assess the potential relationship between the presence of HR-HPV and non-muscle invasive urothelial bladder cancer (NMIBC).
Design: A total of 137 subjects (78 patients affected by NMIBC and 59 controls) were recruited in this prospective study. HR-HPV DNA was evaluated both in urine and tumour tissue. Data from patients were compared with data from controls. The difference between patients and controls in terms of the presence of HR-HPV was estimated. The association between pathological findings and the presence of HR-HPV in the patient group was analysed.
Results: HR-HPV DNA was found in 27 of 78 (34.6%) tumour samples and in 6 of 59 (10.1%) specimens from TUR-P, with a statistically significant difference (p=0.0009; dF=1; Chi square=10.98). HR-HPV DNA in urine was found in 36 of 78 (46.1%) patient samples, but in only 8 of 59 (13.5%) control samples (p<0.0001: dF=1; Chi square=16.37). A statistical significant difference in terms of HR-HPV frequency between high-grade and low-grade urothelial bladder cancer was found (p=0.032; RR=0.52 – 95% CI 0.27-0.93; OR=0.34 – 95% CI 0.13-0.90).
Conclusions: This study highlights the correlation between urothelial bladder cancer and HPV infection, suggesting that HR-HPV may play an aetiological role in the development of urothelial bladder cancer.
Category: Genitourinary (including renal tumors)
Tuesday, March 1, 2011 9:30 AM
Poster Session III # 169, Tuesday Morning