Challenging Benign Fibro-Osseous Lesions of the Craniofacial Complex in Children.
Marisa Yanes, Jose Mota, Sonia Dickson, Patricia Devilliers, Helen Rivera. Central University of Venezuela, Caracas, Venezuela; University of Alabama, Birmingham
Background: Benign fibro-osseous lesions (BFL) are a group of developmental, reactive and neoplastic processes characterized by the replacement of normal bone by fibrous tissue. The WHO reclassified this group, in 2005, into ossifying fibroma, juvenile ossifying fibroma, fibrous dysplasia and osseous dysplasia. The purpose of this study was to analyze the histopathologic characteristics of BFL in children that may help avoid a misdiagnosis.
Design: A total of 4.500 cases from the 2000-2010 archives of the Oral Pathology Laboratory, Faculty of Dentistry, and 902 cases from the 1998- 2010 archives of the Bone Pathology Section, Faculty of Medicine, Central University of Venezuela. All cases corresponding to BFL affecting children were selected. Data according to gender, anatomical location, histologic type and clinical diagnosis were analyzed. STATA (V.10.1) and SPSS (V.18) software and Fisher exact test were used for statistical analysis.
Results: There were ten cases of fibrous dysplasia (FD), six cases of ossifying fibroma (OF), and four of juvenile ossifying fibroma (JOF). The most common misdiagnosis was ossifying fibroma as fibrous dysplasia, due to lack of radiologic and clinical correlation. FD was most commonly observed among females during the first decade. OF was observed mostly in males while JOF was equally distributed. According to anatomic site, craniofacial FD was predominant, OF was most frequently observed in the mandible while JOF was present in the maxilla only.
Conclusions: The present study emphasizes the need to recognize these asymptomatic lesions during the first decade of life, which present with asymmetry, high recurrence rate and aggressive behavior. It is essential to correlate the radiologic, clinical and histologic features to avoid misdiagnosis.
Category: Bone & Soft Tissue
Tuesday, March 1, 2011 9:30 AM
Poster Session III # 11, Tuesday Morning