Detailed Immunohistochemical Characterization in the Spectrum of Sex Cord Stromal Tumors (SCST) of the Testis Using Novel and Established Immunohistochemical (IHC) Markers: A Study of 41 Cases.
Loren P Herrera, Mitual Amin, John D Schwartz, Steven S Shen, Donna E Hansel, Gladell P Paner, Pheroz Tamboli, Komal Arora, Chandrakanth Annaiah, Rugvedita S Parakh, Mahul B Amin. Cedars-Sinai Medical Center, Los Angeles, CA; William Beaumont Hospital, Detroit, MI; The Methodist Hospital, Houston, TX; Cleveland Clinic, OH; University of Chicago, IL; MD Anderson Cancer Center, Houston, TX
Background: SCSTs of the testis are rare accounting for 4% of all testicular neoplasms. They present with a range of architectural & cytologic patterns & a spectrum of differentiation overlapping in their morphology with germ cell tumors, metastatic tumors & paratesticular neoplasms. Immunohistochemistry is a potentially useful diagnostic adjunct in these rare tumors with multiple patterns. SF1-steroidogenic factor 1, a nuclear transcription factor controlling steroidogenesis & development of the gonads, has recently shown to be of value in ovarian tumors – its expression in SCSTs of the testis is largely unknown.
Design: 41 SCSTs encompassing the range seen in the testis were evaluated using traditionally used (inhibin, melanA, calretinin, CD99, S100 and synaptophysin) & novel (SF1) IHC markers.
Results: IHC expression (in percentage) in different SCST subtypes is summarized in the table. Synaptophysin had the lowest positivity rate (17%) amongst all markers studied.