[773] Penile Squamous Cell Carcinomas: Preferential Association of Human Papillomavirus with High Histological Grade.

Alcides Chaux, Fernando Soares, Isabella da Cunha Wernecke, George J Netto, Belen Lloveras, Nubia Munoz, Silvia de Sanjose, F Xavier Bosch, Antonio L Cubilla. Johns Hopkins University, Baltimore, MD; Hospital do Cancer A. C. Camargo, São Paulo, Brazil; Instituto Catalán Oncológico, Barcelona, Spain; CIBER Epidemiologia y Salud Pública, Barcelona, Spain; Instituto de Patología e Investigación, Asunción, Paraguay

Background: Approximately 40% of penile squamous cell carcinomas (SCC) are human papillomavirus (HPV) related and there is controversy regarding the prognostic impact of HPV in this subset of tumors.
Design: SCCs (202 cases) were tested for HPV using SPF-10 PCR. They were categorized in low and high-grade and according to warty and/or basaloid (WB) features. High-grade tumors had anaplastic cells, high nuclear/cytoplasmic ratio, pleomorphism, coarse chromatin, prominent nucleoli, irregular nuclear membrane, and high mitotic/apoptotic rate.
Results: HPV was found in 63 (31%) cases. High-grade features were present in 84 (42%) of all cases. Seventy tumors (35%) showed warty and/or basaloid features. Tables 1 and 2 shown association between HPV status and histological grade in all cases, and according to the presence of WB features, respectively.

Table 1
 No. casesHPV+ (%)HPV- (%)
Low-grade11819 (16)99 (84)
High-grade8444 (52)40 (48)

Table 2
Tumors with WB featuresNo. CasesHPV+ (%)HPV- (%)P-value
Low-grade207 (35)13 (65)P=0.016
High-grade5034 (68)16 (32) 
Tumors without WB featuresNo. CasesHPV+ (%)HPV- (%)P-value
Low-grade9812 (12)86 (88)P=0.031
High-grade3410 (29)24 (71) 

Conclusions: HPV-related penile SCCs were of higher grade than HPV-unrelated tumors. Most HPV related WB carcinomas were of high grade. One third of high-grade non WB carcinomas were also associated with HPV. Knowing the impact of histological grade in the prognosis of patients with penile carcinomas the role of HPV as an adverse factor needs to be considered.
Category: Genitourinary (including renal tumors)

Tuesday, March 1, 2011 1:00 PM

Poster Session IV # 94, Tuesday Afternoon


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