Do Benign Glands at the Resection Margin Increase the Risk of Biochemical Failure Post Radical Prostatectomy?
Susanne M Chan, Francisco J Garcia, Madeleine S Moussa, Joseph L Chin, Manal Y Gabril. London Health Sciences Center/University of Western Ontario, ON, Canada; Division of Urology, London Health Sciences Center/ University of Western Ontario, London, ON, Canada
Background: In radical prostatectomies for prostate cancer (PCa), the effect of benign glands at the resection margins on PSA levels is quesionable. In this study, we compare the risk of biochemical failure post radical prostatectomy in patients who have benign glands at the resection margins vs malignant glands vs no glands.
Design: 58 radical prostatectomies (without neoadjuvant therapy, extraprostatic extension, seminal vesicle invasion or lymph node metastasis) performed by a single surgeon at our institution (1993-2001) were included in this study. All slides from the cases were re-reviewed and pathological features (Gleason grade, PCa volume, margin status (malignant glands, benign glands, no glands at the margin)) were assessed. Clinical data (age, PSA, biochemical failure (3 consecutive rises in PSA with a minimum PSA level of ≥ 0.1 ng/mL), metastasis and survival) was also collected.
|Malignant Glands (n=18)||Benign Glands (n=13)||No Glands (n=27)||P Value|
|Median Age, years||64||61||61||.093|
|Median Preopertive PSA||7.7||6.9||6.8||.767|
|Gleason Score (%)||.150|
|Biochemical Failure (%)||28||8||15||.437|
|Average follow up time (months)||99||97||85|