Status of Helicobacter pylori Infection in Fundic Gland Polyps.
Claudia Velosa, Jan F Silverman. Allegheny General Hospital, Pittsburgh, PA
Background: Fundic gland polyps (FGPs) account for approximately 50% of gastric polyps and are present in approximately 0.8% to 1.9% of all patients undergoing gastroscopy. There is limited literature reporting that patients with FGPs have a low prevalence of H. pylori infection.The aim of this study is to assess prevalence and associations of FGPs and H. pylori infection at our institution.
Design: We conducted a retrospective search of the surgical pathology database from 2007 to 2010 for all FGPs and non-FGPs gastric biopsies. The status of H.pylori was assessed by immunohistochemical staining in all the gastric biopsies.
Results: A total of 8390 gastric biopsies were performed in which 345 (4.1%) FGPs and 8045 (95.9%) non FGPs gastric biopsies were identified. In 405 of 8390 (4.8%) gastric biopsies H. pylori infection was present. 343 of 345 (99.4%) cases of FGPs showed no presence of H.pylori with the microorganism identified in only 2 (0.6 %) cases of FGPs. Of the 405 H. pylori positive cases; 347 (77.9%) were associated with active chronic gastritis, 45 (11.1%) with chronic gastritis, 8 (2.0%) with gastric ulcer, 1 (0.2%) with adenocarcinoma and 4 (1.0%) with non-pathologic diagnosis.
Conclusions: FGPs were present in 4.1% of gastric biopsies analyzed in this study. The prevalence of H. pylori infection in FGPs was very low (0.6%) compared to non-FGP gastric biopsies (4.8%). Our results question the value of doing IHC staining for H. pylori in gastric biopsies of FGPs.
Tuesday, March 1, 2011 9:30 AM
Poster Session III # 144, Tuesday Morning