Five Cases of Indolent Gamma Delta T-Cell Lymphoma (TCL) Localized to the Subcutaneous Panniculus.
Xuan Wang, Cynthia M Magro. New York Presbyterian Hospital-Weill Cornell Medical Center, NY
Background: The WHO EORTC classification of lymphoma designates subcutaneous panniculitis-like T-cell lymphoma (SPTCL) exclusively to alpha beta (αβ) T-cell phenotype. Those of gamma delta (γδ) T-cell type are considered as other forms of primary cutaneous γδ TCL. The basis for this classification was the more indolent course of αβ form compared with the poor 5-year survival of γδ form. However, rare case reports exist of a waxing and waning clinical course in γδ form of SPTCL.
Design: Skin biopsies were studied from 5 patients with γδ TCL localized to the subcutaneous panniculus. A retrospective analysis of clinicopathologic features and follow-up was done.
Results: Clinical features of the 5 γδ TCLs are tabulated below.
|case||age at onset||sex||location||followup period||treatment||outcome|
|1||25||F||leg||7y||fludarabine||complete remission for 5y|
|2||33||F||NA||7y||CHOP + allo stem cell transplant||remission|
|3||36||F||arm thigh leg||7y||systemic chemo 5y after onset||died 7y after onset|
|4||76||F||axilla||0.5y||surgical resection with local radiation||remission|
|5||45||F||wrist leg chest||8y||fludarabin 6y after onset||died 8y after onset|
|case||dermal extension and adnexal involvement||adipocyte rimming||CD5||CD7||CD4/CD8||TIA-1/granzyme||CD56/CD62L|