Differential Expression of CCL5/RANTES in Alpha Beta vs. Gamma Delta Subtypes of Subcutaneous Panniculitis-Like T-Cell Lymphoma (SPTCL).
Xuan Wang, Paul Chadwick, Cynthia M Magro. New York Presbyterian Hospital-Weill Cornell Medical Center, NY
Background: SPTCL has 2 distinct subtypes, alpha beta (αβ) and gamma delta (γδ). The former is generally composed of CD4-CD8+CD56-βF1+ cells with a favorable prognosis and uncommon association with hemophagocytic syndrome (HPS), while the latter is of CD4-CD8-CD56+/-βF1- T-cell phenotype with a poor outcome and frequent manifestation of HPS. The mechanism underlying the prognostic differences is unknown. Recent studies have shown that increased expression of Th1 chemokine, CCL5/RANTES is associated with pathogenesis and disease progression in obesity and atherosclerosis, via recruitment and activation of macrophages and T cells. Whether CCL5 plays a role in SPTCL is unclear.
Design: Skin biopsies were studied from 4 γδ and 3 αβ SPTCLs. IHC results of CCL5, selected T-cell markers and cytotoxic proteins were compared between the two forms of SPTCL.
Results: IHC results are shown below for γδ and αβ forms of SPTCL.
|Subtype of SPTCL||% of CCL5-Postive Cells||CD56||granzyme B||TIA-1||CD5||CD7||CD4/CD8|