Sarcoidosis: Epidemiologic Profile and Autopsy Findings of 22 Cases.
Nella C Fernandez, Roger Smith, Fred Lucas, Qihui J Zhai. University of Cincinnati, OH; Greater Cincinnati Pathologists, Inc, OH
Background: Sarcoidosis, a multisystem disorder of unknown cause affecting young and middle-aged adults, often presents with bilateral hilar lymphadenopathy, pulmonary infiltration, ocular and skin lesions. Other organs may also be involved. The diagnosis is one of exclusion, established when clinicoradiological findings are supported by histological evidence of noncaseating epitheloid cell granulomas. We analyzed the clinical records and autopsy reports of patients seen at a teaching hospital to develop a epidemiologic profile of our population.
Design: 1106 consecutive autopsy cases from January 1st 1999 to July 31st 2010 were reviewed, and decedents with antemortem or postmortem diagnosis of sarcoidosis were included in the cohort. Patients were classified by gender, age, autopsy findings and concomitant conditions.
Results: The male: female ratio was 1:1.The mean age at the time of death was 49.09 years for males and 47.72 years for females. 18 patients were African-American and 4 were Caucasian. Diagnosis of sarcoidosis was antemortem in 13 cases and postmortem in 9. 2 of the cases did not have histological evidence of sarcoidosis on autopsy. The organs involved by the disease in the remaining 20 cases are listed in table 1.
|Organ||Number of cases|
|Lungs||15 / 20|
|Lymph nodes||12 / 20|
|Heart||8 / 20|
|Liver||7 / 20|
|Bone marrow||4 / 20|
|Spleen||3 / 20|
|Kidney||2 / 20|
|Gastrointestinal tract||1 / 20|
|Central nervous system||1 / 20|
|Pancreas||1 / 20|
|Hypertension||14 / 21|
|Diabetes||11 / 21|
|Asthma||8 / 21|
|Kidney disease||8 / 21|
|Liver disease||4 / 21|