Expression of MiTF Can Distinguish Cellular Neurothekeoma from Plexiform Fibrohistiocytic Tumor.
Melanie D Fox, Steven D Billings, Jocelyn Moore, Antoinette B Thomas, Christopher R Shea, Thomas A Victor, Thomas L Cibull. NorthShore University HealthSystem, Evanston Hospital, IL; Cleveland Clinic, OH; University of Chicago, IL
Background: Overlapping histopathologic features of cellular neurothekeoma (CNT) and plexiform fibrohistiocytic tumor (PFHT) predominantly composed of histiocytic cells, make distinction between these entities challenging. Some have suggested that CNT and PFHT are related entities. No prior study has demonstrated a reliable immunohistochemical panel to differentiate these entities.
Design: Cases diagnosed as CNT and PFHT, from 2004-2010 were retrieved from the pathology departments of Evanston Hospital, Cleveland Clinic and The University of Chicago with accompanying pathology reports. Each case was reviewed by at least two dermatopathologists for confirmation of diagnosis. All cases were stained for PAX2, NKIC3, CD10 and MiTF.
|10||F||Left upper arm||CNT||2+||3+||3+||3+|