Treatment of Psoriasis with Biologics Modulates the Expression of TNF-Alpha and Its Receptors.
Claudio Di Cristofano, Ilaria Proietti, Jessica Cacciotti, Nicoletta Bernardini, Barbara Sardella, Martina Leopizzi, Caterina Chiappetta, Antonella Miraglia, Nevena Skroza, Vincenzo Petrozza, Concetta Potenza, Carlo Della Rocca. Sapienza University of Rome, Italy
Background: The psoriasis is driven by activated T cells which release various cytokines that leading to proliferation and abnormal differentiation of keratinocytes. br]Elevated levels of TNF-alpha have been demonstrated in psoriatic skin lesions. TNF-alpha has a direct role in the development, proliferation, and maintenance of psoriatic plaques. It is a suitable drugs target for psoriasis treatment. Two distinct soluble TNF receptors have been identified, p55 (TNF-R1) and p75 (TNF-R2). We evaluated the clinical results, histopathological aspect and immunohistochemical expression of TNF-alpha and its receptors in skin biopsy before and after anti-TNF-alpha treatment.
Design: We have selected 40 patients with to moderate to severe psoriasis treated with anti-TNF-alpha biological drugs. Patients underwent skin biopsy at baseline and after 12 weeks. The skin biopsies were evaluated histologically and were tested the immunohistochemical expression of TNF-alpha, TNF-R1 and TNF-R2.
Results: We found high TNF-alpha, TNF-R1 and TNF-R2 expressions in early phase of psoriasis and in psoriasic lesions before treatment. The responsive patients were associate to presence in psoriasis lesions of ortocheratosis (p=0,04), proliferation of capillaries (p=0,01) and lymphocytic infiltrate (p=0,04) in dermal and with TNF-alpha endothelial expression (p=0,003).
Conclusions: TNF-alpha and its receptors expression change during the progression of plaque psoriasis. Anti-TNF-alpha therapy of psoriasis decrease the TNF-alpha and its receptors expressions. The morphology and cytokines expression in psoriasis could be helpful on deciding the treatment.
Wednesday, March 2, 2011 1:00 PM
Poster Session VI # 126, Wednesday Afternoon