Fascin as an Identifier of Metastatic Urothelial Carcinoma: A Retrospective Study of Fine Needle Aspirations.
Adam P Vogt, Cynthia Cohen, Momin T Siddiqui. Emory University School of Medicine, Atlanta, GA
Background: Fascin immunohistochemical (IHC) staining has been shown to be a useful marker to determine invasion of urothelial carcinoma. Currently, thrombomodulin is the preferred marker for determination of primary site of metastatic disease in patients with concurrent or previously diagnosed urothelial carcinoma. Fascin, a marker of invasiveness, has not been correlated with metastatic disease. To enhance diagnostic accuracy and correctly identify primary site for appropriate patient management, fascin may be a useful marker in metastatic urothelial carcinoma.
Design: Twenty five cases with adequate cell block material for IHC staining were identified in surgical pathology and cytopathology files of metastatic urothelial carcinoma with either concurrent or previously resected urothelial carcinoma between 2005 and 2010. Fascin, thrombomodulin, uroplakin, cytokeratin 7, and cytokeratin 20 IHC were performed on paraffin-embedded cell block serial sections. Tissue microarrays with two 1mm cores of each of 26 renal and 46 prostate carcinomas were immunostained for fascin.