The Diagnostic Value of Cell Block from Liquid-Based Bronchial Washings Cytology Specimens in the Diagnosis and Subclassification of Pulmonary Neoplasms.
George Collins, Songlin Zhang, Jaiyeola Thomas. Louisiana State University Health Sciences Center-Shreveport, Shreveport
Background: Though cell block (CB) preparations of bronchial washings cytology specimens are routinely done in our institution, its diagnostic value has received little attention in the literature. The diagnostic value of routine CB as adjunct to liquid based (ThinPrep) bronchial washing cytology preparations (LBC) in the detection and subclassification of pulmonary neoplasms has not been evaluated. This study aims to evaluate the diagnostic utility of CB in this setting.
Design: This study included all 74 bronchial washings samples and CB diagnosed as malignant or suspicious/atypical from bronchoscopies done in our institution during 2009. 28 randomly selected negative cases were also reviewed. The LBC and CB preparations were reviewed independently. Deeper levels, ancillary stains, and PCR analysis were done on CB when necessary for specific classification of tumors. LBC and CB diagnoses were compared and correlated with final histology/bronchial brushing diagnoses.
Results: LBC and CB yielded adequate material for diagnosis in all cases. Table 1 shows the correlation of CB and LBC diagnoses.
|LBC diagnosis (# of cases)||Cell Block diagnosis (# of cases)|
|Positive (29)||Suspicious (9)||Atypical( 26)||Negative (38)|